What Is DSIP?
DSIP (Delta Sleep-Inducing Peptide) is a nonapeptide with the primary sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, first isolated from venous blood of hypothalamus-stimulated rabbits exhibiting delta-wave EEG activity. Despite its name originating from this initial characterisation, DSIP exhibits a remarkably broad neuroendocrine regulatory profile extending well beyond sleep architecture. Its presence has been detected in the hypothalamus, pituitary, adrenal glands, gonads, and gastrointestinal tract, suggesting pleiotropic roles across multiple regulatory axes.
Research models have investigated DSIP in the context of hypothalamic-pituitary axis regulation — particularly pulsatile LH and GH secretion, where it appears to act as a modulator of endogenous release patterns rather than a direct stimulator. Additional research has examined DSIP in HPA axis stress response characterisation (cortisol/ACTH pulsatility), neuroprotective mechanisms under oxidative stress conditions, and potential GABAergic pathway interactions. The peptide's unusual multi-axis neuroendocrine profile has made it an active area of exploration in sleep research, stress physiology, and hypothalamic neurobiology.
For GABAergic anxiolytic neuropeptide research, see Selank (SL05 / SL10). For related neuropeptide and nootropic research, see Semax (SX05 / SX10). For research use only.
DSIP Products
Supplied as lyophilised powder in boxes of 10 research-grade vials.
Quality Assurance
Frequently Asked Questions
Where can I buy DSIP in Australia?
Eternal Peptides Wholesale is an Australian-owned, ABN-registered wholesale distributor. DS10 (DSIP 10mg, box of 10) is $544.50. Every batch carries a Janoshik Analytical COA. Orders dispatched within 1-2 business days from Australia. For research use only.
What is the full name and sequence of DSIP?
DSIP stands for Delta Sleep-Inducing Peptide. The primary amino acid sequence is Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu (WAGGDAS GE in single-letter notation), a nonapeptide with MW approximately 848 Da. It was originally isolated from venous blood of rabbits following hypothalamic stimulation during delta-wave EEG activity, hence the name. For research use only.
What neuroendocrine axes has DSIP been studied in?
Research has investigated DSIP across several axes: (1) sleep regulation — delta-wave sleep induction, sleep architecture modulation; (2) HPG axis — pulsatile LH and testosterone secretion modulation in rodent models; (3) HPA axis — cortisol and ACTH pulsatility, stress response attenuation; (4) GH axis — GH release pattern modulation; and (5) neuroprotective effects under oxidative stress conditions. For research use only.
How does DSIP differ from Selank in neuropeptide research?
Both are neuropeptides studied in stress/anxiety research models, but through different mechanisms. DSIP is a nonapeptide acting on hypothalamic sleep-wake regulation, pulsatile hormone rhythms, and HPA axis stress responses. Selank is a synthetic heptapeptide derived from tuftsin, acting primarily via GABAergic and serotonergic pathways with a clearer anxiolytic mechanism. Research applications overlap in stress physiology but differ substantially in their primary mechanisms. For research use only.