What Is IGF-1 LR3?
IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a synthetic 83-amino acid analogue of human IGF-1, modified at two positions: an N-terminal 13-amino acid extension and substitution of Glu→Arg at position 3. The critical consequence of these modifications is a greater than 1000-fold reduction in affinity for all six insulin-like growth factor binding proteins (IGFBPs 1-6), which in native IGF-1 account for the majority of plasma binding and limit free IGF-1 concentrations.
By bypassing IGFBP sequestration, IGF-1 LR3 displays a dramatically extended effective half-life in research models, making it the preferred research tool for studying sustained IGF-1 receptor (IGF-1R) activation. Downstream signalling via PI3K/Akt (anabolic/survival) and MAPK/ERK (proliferative) pathways is well-characterised in the preclinical muscle, metabolic, and oncology research literature.
For GH axis upstream research, see Sermorelin or CJC-1295 + Ipamorelin. For research use only.
IGF-1 LR3 Products
Supplied as lyophilised powder in boxes of 10 research-grade vials.
Frequently Asked Questions
Where can I buy IGF-1 LR3 in Australia? +
Eternal Peptides Wholesale is an Australian-owned, ABN-registered distributor supplying IGF-1 LR3 for research purposes. IG10 (1mg, box of 10) is $1,188.00. Janoshik-verified with COA on product page. Dispatched within 1-2 business days. For research use only.
Why use IGF-1 LR3 instead of native IGF-1? +
Native IGF-1 is heavily sequestered by IGFBPs in plasma, which limits free IGF-1 and shortens its effective half-life. IGF-1 LR3's >1000-fold reduced IGFBP affinity means it remains bioavailable for IGF-1R activation over much longer timeframes — making it the research-preferred form for studying sustained IGF-1R-mediated signalling. For research use only.
What pathways does IGF-1 LR3 activate in research models? +
IGF-1 LR3 activates the IGF-1 receptor (IGF-1R), stimulating PI3K/Akt/mTOR signalling (protein synthesis, cell survival, anabolic) and MAPK/ERK signalling (cell proliferation, differentiation). These pathways are central to skeletal muscle hypertrophy, metabolic regulation, and cell growth research. For research use only.
How is IGF-1 LR3 quality verified? +
Every batch tested by Janoshik Analytical — HPLC purity, mass spectrometry identity, sterility (USP), endotoxin (LAL), heavy metals (ICP-MS). COA independently verifiable at janoshik.com. For research use only.
How quickly is IG10 dispatched? +
Orders dispatched within 1-2 business days of payment confirmation from Australia. COA included with every order.